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Peptide record

TPDB00173

ACE inhibitor from alphas1-casein ACE inhibitors Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB00173
ACE inhibitor from alphas1-casein
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
AYFYPE
Physicochemical Analysis
C40H48N6O11
RNDCQGHILKMSTWV
Y
788.85
3.29
0
1
4
-1
-0.71
-0.517
16.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
377.76
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
6
C40H48N6O11
788.85
3.29
-1
-0.71
-0.517
788.8408
788.3369
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
106.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Yamamoto N., Akino A., Takano T.
Antihypertensive effects of peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 77, 917-922, 1994
1994
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C40H48N6O11/c1-23(41)35(51)43-30(21-25-9-13-27(47)14-10-25)36(52)44-31(20-24-6-3-2-4-7-24)37(53)45-32(22-26-11-15-28(48)16-12-26)39(55)46-19-5-8-33(46)38(54)42-29(40(56)57)17-18-34(49)50/h2-4,6-7,9-16,23,29-33,47-48H,5,8,17-22,41H2,1H3,(H,42,54)(H,43,51)(H,44,52)(H,45,53)(H,49,50)(H,56,57)/t23-,29-,30-,31-,32-,33-/m0/s1 InChIKey=MJSMBGMARRSHGO-XDGMXVDYSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10061) the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
106.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Yamamoto N., Akino A., Takano T.
Antihypertensive effects of peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 77, 917-922, 1994
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C40H48N6O11/c1-23(41)35(51)43-30(21-25-9-13-27(47)14-10-25)36(52)44-31(20-24-6-3-2-4-7-24)37(53)45-32(22-26-11-15-28(48)16-12-26)39(55)46-19-5-8-33(46)38(54)42-29(40(56)57)17-18-34(49)50/h2-4,6-7,9-16,23,29-33,47-48H,5,8,17-22,41H2,1H3,(H,42,54)(H,43,51)(H,44,52)(H,45,53)(H,49,50)(H,56,57)/t23-,29-,30-,31-,32-,33-/m0/s1 InChIKey=MJSMBGMARRSHGO-XDGMXVDYSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10061) the MBPDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb FermFooDB
DFBP
Additional Detail Fields 1 fields
6