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Peptide record

TPDB00149

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic Antioxidant standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB00149
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AODB Multi-AOP
standard
No
A 13-aa standard natural multi-activity (Antidiabetic and Antioxidant) peptide sequence curated from Peptipedia, AODB, and Multi-AOP, with an available 3D structural model.
Sequence
ASGLCPEEAVPRR
Physicochemical Analysis
C57H97N19O19S1
NDQHIKMFTWY
AREP
1384.57
6.43
2
2
4
-0
5.63
-0.485
67.69
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
2
R
0
N
0
D
1
C
2
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C57H97N19O19S1
1384.57
6.43
-0
5.63
-0.485
1384.5582
1383.6907
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
2.20 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Thakur S., Chhimwal J., Joshi R., Kumari M., Padwad Y., Kumar R.
Evaluating peptides of picrorhiza kurroa and their inhibitory potential against ACE, DPP-IV, and oxidative stress. J Proteome Res, 20 (8), 3798–3813, 2021
2021
Journal

Other

13
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C57H97N19O19S/c1-27(2)23-35(67-40(78)24-65-46(85)36(25-77)72-44(83)29(5)58)50(89)73-37(26-96)53(92)75-21-9-13-38(75)51(90)70-33(16-18-42(81)82)49(88)68-32(15-17-41(79)80)47(86)66-30(6)45(84)74-43(28(3)4)54(93)76-22-10-14-39(76)52(91)69-31(11-7-19-63-56(59)60)48(87)71-34(55(94)95)12-8-20-64-57(61)62/h27-39,43,77,96H,7-26,58H2,1-6H3,(H,65,85)(H,66,86)(H,67,78)(H,68,88)(H,69,91)(H,70,90)(H,71,87)(H,72,83)(H,73,89)(H,74,84)(H,79,80)(H,81,82)(H,94,95)(H4,59,60,63)(H4,61,62,64)/t29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,43-/m0/s1 InChIKey= WCGDZHPDQFDMKR-NWULDMBASA-N
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
13