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Peptide record

TPDB00098

Antibacterial Anticancer Antifungal Antioxidant Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB00098
Antibacterial Anticancer Antifungal Antioxidant Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 dbACP iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ALWKDILKNAGKAALNEINQIVQ
Physicochemical Analysis
C115H192N32O33
RCHMFPSTY
A
2550.98
9.76
3
2
12
+1
3.58
-0.052
131.74
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
215.60
5
Residue Composition
number
4
A
0
R
3
N
1
D
0
C
1
E
2
Q
1
G
0
H
3
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 1 C: 0 E: 1 Q: 2 G: 1 H: 0 I: 3 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C115H192N32O33
2550.98
9.76
+1
3.58
-0.052
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli NCTC 10418

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli NCTC 10418 (MIC 32 uM) and C. albicans NCYC 1467 (MIC 64 uM). Inactive: S.aureus NCTC 10788 (MIC 256 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µM

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP DRAMP

Other

Active against E. coli NCTC 10418 (MIC 32 uM) and C. albicans NCYC 1467 (MIC 64 uM). Inactive: S.aureus NCTC 10788 (MIC 256 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
256 µM

Target

S.aureus NCTC 10788

Source & Reference

dbAMP DRAMP

Other

e against E. coli NCTC 10418 (MIC 32 uM) and C. albicans NCYC 1467 (MIC 64 uM). Inactive: S.aureus NCTC 10788 (MIC 256 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli NCTC 10418

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli NCTC 10418 (MIC 32 uM) and C. albicans NCYC 1467 (MIC 64 uM). Inactive: S.aureus NCTC 10788 (MIC 256 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
64 µM

Target

Candida albicans NCYC 1467

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli NCTC 10418 (MIC 32 uM) and C. albicans NCYC 1467 (MIC 64 uM). Inactive: S.aureus NCTC 10788 (MIC 256 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
256 µM

Target

S.aureus NCTC 10788

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e against E. coli NCTC 10418 (MIC 32 uM) and C. albicans NCYC 1467 (MIC 64 uM). Inactive: S.aureus NCTC 10788 (MIC 256 uM).
Evidence 7 Activity

Activity

IC50
Toxicity
132.10 µM
Cytotoxic
IC50 | 132.10 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii. | Toxins (Basel) | 2018
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
138.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 138.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii. | Toxins (Basel) | 2018
Evidence 9 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:PubMed ID is not available]5% hemolytic activity at 128 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Submitted (AUG-2006) to UniProtKB.