TPDB

3D PDB MODEL

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TPDB ID TPDB00078

Activity

Antibacterial Antifungal Antioxidant

Activity_category_statistics

Anti-infective peptides Functional / health-promoting peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AnOxPePred - 1.0 AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial, Antifungal, and Antioxidant) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

AKAWGIPPHVIPQIVPVRIRPLCGNV

FASTA

>TPDB00078|Antibacterial;Antifungal;Antioxidant|length=26
AKAWGIPPHVIPQIVPVRIRPLCGNV

Formula C132H216N38O29S1

Absent Amino Acids DEMFSTY

Common Amino Acids P

Mass 2831.46

PI 11.32

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +3

Boman Index 2.89

Hydrophobicity 0.458

Aliphatic Index 127.31

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 194.25

Polar Residues 3

number

2

A

2

R

1

N

0

D

1

C

0

E

1

Q

2

G

1

H

4

I

1

L

1

K

0

M

0

F

5

P

0

S

0

T

1

W

0

Y

4

V

Amino Acid Distribution

A: 2 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 1 I: 4 L: 1 K: 1 M: 0 F: 0 P: 5 S: 0 T: 0 W: 1 Y: 0 V: 4

Length

26

Formula

C132H216N38O29S1

Mass

2831.46

PI

11.32

Net Charge

+3

Boman Index

2.89

Hydrophobicity

0.458

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 25 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B.subtilis ATCC 6633 (>200 ug/ml), and C. albicans ATCC2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

22 (MIC 25 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B.subtilis ATCC 6633 (>200 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Also antioxidant. Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 25 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B.subtilis ATCC 6633 (>200 ug/ml), and C. albicans ATCC2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

22 (MIC 25 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B.subtilis ATCC 6633 (>200 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Also antioxidant. Updated 7/2021