TPDB

3D PDB MODEL

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TPDB ID TPDB00072

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

AIGVGAIER

FASTA

>TPDB00072|ACE inhibitors;Antioxidant|length=9
AIGVGAIER

Formula C38H68N12O12

Absent Amino Acids NDCQHLKMFPSTWY

Common Amino Acids AGI

Mass 885.03

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -0

Boman Index 1.96

Hydrophobicity 0.889

Aliphatic Index 141.11

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

1

R

0

N

0

D

0

C

1

E

0

Q

2

G

0

H

2

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

9

Formula

C38H68N12O12

Mass

885.03

PI

6.97

Net Charge

-0

Boman Index

1.96

Hydrophobicity

0.889

Chemical_Mass

885.0170

Monoisotopic_Mass

884.5064

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 16.31 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C38H68N12O12/c1-9-19(5)29(49-31(55)21(7)39)35(59)44-17-26(52)48-28(18(3)4)34(58)43-16-25(51)45-22(8)32(56)50-30(20(6)10-2)36(60)46-23(13-14-27(53)54)33(57)47-24(37(61)62)12-11-15-42-38(40)41/h18-24,28-30H,9-17,39H2,1-8H3,(H,43,58)(H,44,59)(H,45,51)(H,46,60)(H,47,57)(H,48,52)(H,49,55)(H,50,56)(H,53,54)(H,61,62)(H4,40,41,42)/t19-,20-,21-,22-,23-,24-,28-,29-,30-/m0/s1 InChIKey=ZUMQZVQMEVLCAX-RBXVSGTMSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9841) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9842) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9445)

Number_of_Residues

9