TPDB

3D PDB MODEL

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TPDB ID TPDB00048

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant Bitter Umami

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP Tastepeptides-Meta

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors, Antioxidant, Bitter, and other sources) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

AGDDAPR

FASTA

>TPDB00048|ACE inhibitors;Antioxidant;Bitter;Umami|length=7
AGDDAPR

Formula C27H44N10O12

Absent Amino Acids NCEQHILKMFSTWYV

Common Amino Acids AD

Mass 700.71

PI 3.88

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -1

Boman Index 3.39

Hydrophobicity -1.414

Aliphatic Index 28.57

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

1

R

0

N

2

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C27H44N10O12

Mass

700.71

PI

3.88

Net Charge

-1

Boman Index

3.39

Hydrophobicity

-1.414

Chemical_Mass

700.6963

Monoisotopic_Mass

700.3130

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 11.91 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C27H44N10O12/c1-12(28)21(43)32-11-18(38)34-15(9-19(39)40)23(45)36-16(10-20(41)42)22(44)33-13(2)25(47)37-8-4-6-17(37)24(46)35-14(26(48)49)5-3-7-31-27(29)30/h12-17H,3-11,28H2,1-2H3,(H,32,43)(H,33,44)(H,34,38)(H,35,46)(H,36,45)(H,39,40)(H,41,42)(H,48,49)(H4,29,30,31)/t12-,13-,14-,15-,16-,17-/m0/s1 InChIKey=DWTQGNOZCAMFKL-UYLCUJDWSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9443) Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9835) Inhibitor of Alpha-glucosidase (EC 3.2.1.1) according to the BIOPEP-UWM database of bioactive peptides (ID 9836)

Number_of_Residues

7