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Peptide record

TPDB00026

ACE inhibitor ACE inhibitors Antioxidant standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB00026
ACE inhibitor
ACE inhibitors Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AODB AoXpDb Multi-AOP
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.
Sequence
ADVFNPR
Physicochemical Analysis
C36H55N11O11
CEQGHILKMSTWY
ARNDFPV
817.90
6.78
1
1
3
-0
1.68
-0.614
55.71
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C36H55N11O11
817.90
6.78
-0
1.68
-0.614
817.8868
817.4070
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
485.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Zheng Y., Li Y., Zhang Y., Ruan X., Zhang R.
Purification, characterization, synthesis, in vitro ACE inhibition and in vivo antihypertensive activity of bioactive peptides derived from oil palm kernel glutelin-2 hydrolysates. J. Funct. Foods, 28, 48-58, 2017
2017
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C36H55N11O11/c1-18(2)28(46-31(53)23(17-27(49)50)43-29(51)19(3)37)33(55)44-22(15-20-9-5-4-6-10-20)30(52)45-24(16-26(38)48)34(56)47-14-8-12-25(47)32(54)42-21(35(57)58)11-7-13-41-36(39)40/h4-6,9-10,18-19,21-25,28H,7-8,11-17,37H2,1-3H3,(H2,38,48)(H,42,54)(H,43,51)(H,44,55)(H,45,52)(H,46,53)(H,49,50)(H,57,58)(H4,39,40,41)/t19-,21-,22-,23-,24-,25-,28-/m0/s1 InChIKey: KDGPICQIDWPGDU-IVXOHGEOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9711) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9712)
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
7