TPDB

3D PDB MODEL

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TPDB ID TPDB00004

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

AAAPVAVAK

FASTA

>TPDB00004|ACE inhibitors;Antioxidant|length=9
AAAPVAVAK

Formula C36H64N10O10

Absent Amino Acids RNDCEQGHILMFSTWY

Common Amino Acids A

Mass 796.97

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +1

Boman Index 0.73

Hydrophobicity 1.322

Aliphatic Index 120.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

5

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 5 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

9

Formula

C36H64N10O10

Mass

796.97

PI

10.10

Net Charge

+1

Boman Index

0.73

Hydrophobicity

1.322

Chemical_Mass

796.9518

Monoisotopic_Mass

796.4792

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 10.45 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C36H64N10O10/c1-17(2)26(33(52)40-21(7)30(49)43-24(36(55)56)13-10-11-15-37)44-31(50)22(8)41-34(53)27(18(3)4)45-32(51)25-14-12-16-46(25)35(54)23(9)42-29(48)20(6)39-28(47)19(5)38/h17-27H,10-16,37-38H2,1-9H3,(H,39,47)(H,40,52)(H,41,53)(H,42,48)(H,43,49)(H,44,50)(H,45,51)(H,55,56)/t19-,20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 InChIKey=WUQCVEBPAYSGPV-JOXZBDCSSA-N Pancreatic lipase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 9830) Inhibitor of Alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9831) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9441)

Number_of_Residues

9